PMID:1368181
| Citation |
Wanner, BL (1992) Genes for phosphonate biodegradation in Escherichia coli. SAAS Bull. Biochem. Biotechnol. 5:1-6 |
|---|---|
| Abstract |
Escherichia coli has a carbon-phosphorus (C-P) lyase with a broad substrate specificity, whose synthesis is induced many hundred fold during phosphate (Pi) limitation. Fourteen genes for phosphonate metabolism comprise the phnC-to-phnP gene cluster: three gene products (PhnC, PhnD, and PhnE) comprise a binding protein-dependent phosphonate transporter, which also transports Pi and phosphate esters; two gene products (PhnF and PhnO) may have a role in gene regulation; and nine gene products (PhnG, PhnH, PhnI, PhnJ, PhnK, PhnL, PhnM, PhnN, and PhnP) may comprise a C-P lyase enzyme complex. Phosphonate biodegradation via a C-P lyase appears to be limited by the specificity of the PhnCDE transporter and not by the specificity of the C-P lyase. These interpretations are based on results from a combination of molecular genetic and molecular biological studies on phosphonate metabolism in E. coli. |
| Links | |
| Keywords |
Biodegradation, Environmental; Escherichia coli/genetics; Genes, Bacterial; Lyases/genetics; Multigene Family; Organophosphonates/metabolism; Phosphates/metabolism |
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