PMID:135755
| Citation |
Bassford, PJ Jr, Bradbeer, C, Kadner, RJ and Schnaitman, CA (1976) Transport of vitamin B12 in tonB mutants of Escherichia coli. J. Bacteriol. 128:242-7 |
|---|---|
| Abstract |
It is known that the tonB mutation in Escherichia coli is responsible for a defect in the transport of iron chelates. These are transported by systems that involve outer membrane components. We found that tonB mutants were also deficient in the secondary, energy-dependent phase of vitamin B12 transport, although the mutants have normal levels of B12 receptors on their cell surface. In addition, tonB mutants derived from vitamin B12 auxotrophs required elevated levels of B12 for normal growth. Maltose uptake, mediated by another transport system involving an outer membrane component, was unaffected by the tonB mutation. |
| Links | |
| Keywords |
Amino Acids/metabolism; Biological Transport, Active; Enterobactin/metabolism; Escherichia coli/growth & development; Escherichia coli/metabolism; Genes; Maltose/metabolism; Mutation; Protein Biosynthesis; Receptors, Drug; Vitamin B 12/metabolism |
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