PMID:1357526
| Citation |
Marklund, BI, Tennent, JM, Garcia, E, Hamers, A, Båga, M, Lindberg, F, Gaastra, W and Normark, S (1992) Horizontal gene transfer of the Escherichia coli pap and prs pili operons as a mechanism for the development of tissue-specific adhesive properties. Mol. Microbiol. 6:2225-42 |
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| Abstract |
Escherichia coli strains bind to Gal alpha 1-4Gal-containing glycolipids via P pili-associated G-adhesins. Three functional classes of adhesins with different binding specificities are encoded by conserved G-alleles. We suggest that the Class I papG-allele of strain J96 is a novel acquisition possibly introduced via horizontal gene transfer into one of the two P pili gene clusters carried by this strain. Closely related strains in the ECOR collection of natural E. coli isolates carry either a Class II or a Class III G-adhesin. Data indicate that genetic exchanges involving either entire pap or prs gene clusters or individual pap/prs genes have occurred. We propose that the retention and spread of pap/prs DNA among E. coli is the result of selection pressure exerted by mammalian intestinal isoreceptors. |
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| Keywords |
Adhesins, Escherichia coli; Alleles; Amino Acid Sequence; Animals; Bacterial Adhesion/genetics; Bacterial Outer Membrane Proteins/genetics; Base Sequence; Biological Evolution; Carbohydrate Sequence; DNA, Bacterial; Escherichia coli/genetics; Fimbriae, Bacterial; Humans; Molecular Sequence Data; Multigene Family; Operon; Restriction Mapping; Sequence Homology; Transfection |
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