PMID:1304914
| Citation |
Reizer, J, Reizer, A, Saier, MH Jr and Jacobson, GR (1992) A proposed link between nitrogen and carbon metabolism involving protein phosphorylation in bacteria. Protein Sci. 1:722-6 |
|---|---|
| Abstract |
We demonstrate that certain phosphoryl transfer proteins of the bacterial phosphotransferase system (PTS), the fructose- and mannitol-specific IIA proteins or domains, are homologous to a class of proteins, one of which is known to affect transcription of some of the nitrogen-regulatory sigma 54-dependent operons in Klebsiella pneumoniae. The phosphorylatable histidyl residue in the homologous PTS proteins and the consensus sequence in the vicinity of the active-site histidine are fully conserved in all members that comprise this family of proteins. A phylogenetic tree of the eight protein members of this family was constructed, and a "signature" sequence that can serve for the identification of new protein members of this family is proposed. These observations suggest that PTS-catalyzed protein phosphorylation may provide a regulatory link between carbon and nitrogen assimilation in bacteria. |
| Links |
PubMed PMC2142240 Online version:10.1002/pro.5560010604 |
| Keywords |
Amino Acid Sequence; Bacteria/enzymology; Bacteria/genetics; Carbon/metabolism; Fructose/metabolism; Klebsiella pneumoniae/enzymology; Klebsiella pneumoniae/genetics; Mannitol/metabolism; Molecular Sequence Data; Nitrogen/metabolism; Open Reading Frames; Operon; Phosphoenolpyruvate Sugar Phosphotransferase System/genetics; Phosphoenolpyruvate Sugar Phosphotransferase System/metabolism; Phosphorylation; Phylogeny; Sequence Homology, Amino Acid; Sigma Factor/metabolism; Transcription, Genetic |
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