PMID:12951338
| Citation |
Hirakawa, H, Nishino, K, Yamada, J, Hirata, T and Yamaguchi, A (2003) Beta-lactam resistance modulated by the overexpression of response regulators of two-component signal transduction systems in Escherichia coli. J. Antimicrob. Chemother. 52:576-82 |
|---|---|
| Abstract |
In Escherichia coli, there are 32 open reading frames assumed, on the basis of sequence similarities, to be response regulator genes of two-component signal transduction systems. We cloned all 32 response regulators and examined whether or not response regulator-overexpressing cells confer resistance to beta-lactam antibiotics in E. coli. |
| Links |
PubMed Online version:10.1093/jac/dkg406 |
| Keywords |
Bacterial Proteins/antagonists & inhibitors; Bacterial Proteins/biosynthesis; Bacterial Proteins/genetics; Carrier Proteins/biosynthesis; Carrier Proteins/genetics; Drug Resistance, Microbial/genetics; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli Proteins/biosynthesis; Escherichia coli Proteins/genetics; Gene Expression Regulation, Bacterial/genetics; Lipoproteins/biosynthesis; Lipoproteins/genetics; Membrane Proteins/biosynthesis; Membrane Proteins/genetics; Membrane Transport Proteins/biosynthesis; Membrane Transport Proteins/genetics; Microbial Sensitivity Tests/methods; Multidrug Resistance-Associated Proteins; Open Reading Frames/genetics; Signal Transduction/genetics; Transcription Factors/antagonists & inhibitors; Transcription Factors/genetics; beta-Lactam Resistance/genetics; beta-Lactamases/biosynthesis; beta-Lactamases/genetics |
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