PMID:12948773
| Citation |
Perozo, E and Rees, DC (2003) Structure and mechanism in prokaryotic mechanosensitive channels. Curr. Opin. Struct. Biol. 13:432-42 |
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| Abstract |
Mechanosensitive channels function as electromechanical switches with the capability to sense the physical state of lipid bilayers. The X-ray crystal structures of MscL and MscS offer a unique opportunity to identify the types of protein motions associated with the opening and closing of these structurally unrelated channels, while providing the framework to address a mechanism of tension sensing that is defined by channel-lipid interactions. Recent functional, structural and dynamic data offer fresh insights into the molecular basis of gating for these membrane proteins. |
| Links | |
| Keywords |
Cell Membrane/genetics; Cell Membrane/physiology; Escherichia coli/genetics; Escherichia coli/physiology; Escherichia coli Proteins/genetics; Escherichia coli Proteins/physiology; Ion Channels/genetics; Ion Channels/physiology; Mechanotransduction, Cellular/genetics; Mechanotransduction, Cellular/physiology |
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