PMID:12940821
| Citation |
Su'etsugu, M, Emoto, A, Fujimitsu, K, Keyamura, K and Katayama, T (2003) Transcriptional control for initiation of chromosomal replication in Escherichia coli: fluctuation of the level of origin transcription ensures timely initiation. Genes Cells 8:731-45 |
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| Abstract |
During the cell cycle, the initiation of chromosomal replication is strictly controlled. In Escherichia coli, the initiator DnaA and the replication origin oriC are major targets for this regulation. Here, we assessed the role of transcription of the mioC gene, which reads through the adjacent oriC region. This mioC-oriC transcription is regulated in coordination with the replication cycle so that it is activated after initiation and repressed before initiation. |
| Links | |
| Keywords |
Bacterial Outer Membrane Proteins/physiology; Bacterial Proteins/genetics; Base Sequence; Cell Cycle; Cell Division; Chromosomes, Bacterial; DNA Replication; DNA Replication Timing; DNA Transposable Elements; DNA-Binding Proteins/genetics; DNA-Binding Proteins/physiology; Escherichia coli/cytology; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli Proteins/biosynthesis; Escherichia coli Proteins/genetics; Escherichia coli Proteins/physiology; Flavoproteins/biosynthesis; Flavoproteins/genetics; Molecular Sequence Data; Mutation; Promoter Regions, Genetic; RNA, Bacterial/biosynthesis; Replication Origin; Temperature; Transcription, Genetic |
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