PMID:12940820
| Citation |
Hishida, T, Iwasaki, H, Han, YW, Ohnishi, T and Shinagawa, H (2003) Uncoupling of the ATPase activity from the branch migration activity of RuvAB protein complexes containing both wild-type and ATPase-defective RuvB proteins. Genes Cells 8:721-30 |
|---|---|
| Abstract |
Escherichia coli RuvAB promotes branch migration of Holliday junctions during recombination repair and homologous recombination. RuvB forms a hexameric ring through which duplex DNA passes and is translocated in an ATP-dependent manner. ATPase-deficient RuvB mutant K68A has a mutation in the Walker A motif and exerts a dominant-negative effect on in vivo repair of UV-induced DNA damage. In this study, we examined RuvAB-dependent branch migration in the presence of a mutant RuvB, K68A. |
| Links | |
| Keywords |
Adenosine Triphosphatases/metabolism; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; DNA Helicases; DNA-Binding Proteins/metabolism; Escherichia coli Proteins; Macromolecular Substances; Mutation; Rec A Recombinases/metabolism; Recombination, Genetic |
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