PMID:12923108
| Citation |
Boston, T and Atlung, T (2003) FNR-mediated oxygen-responsive regulation of the nrdDG operon of Escherichia coli. J. Bacteriol. 185:5310-3 |
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| Abstract |
Transcription of the nrdDG operon, which encodes the class III nucleotide reductase, which is only active under anaerobic conditions, was strongly induced after a shift to anaerobiosis. The induction was completely dependent on the transcriptional activator FNR and was independent of the ArcA-ArcB two-component response regulator system. The nrdD transcript start site was mapped to a position immediately downstream of two FNR binding sites. Transcription of the other two nucleotide reductase operons, nrdAB and nrdEF, did not respond to oxygen conditions in a wild-type background, but nrdAB expression was increased in the fnr mutant under anaerobic conditions. |
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| Keywords |
Aerobiosis; Anaerobiosis; Escherichia coli/genetics; Escherichia coli/growth & development; Escherichia coli/metabolism; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Gene Expression Regulation, Bacterial; Iron-Sulfur Proteins/metabolism; Operon; Oxygen/metabolism; Ribonucleotide Reductases/genetics; Ribonucleotide Reductases/metabolism; Transcription, Genetic; Viral Proteins/genetics; Viral Proteins/metabolism |
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