PMID:12903130

Citation	*Hori, Y, Bichenkova, EV, Wilton, AN, Tanaka, T, Douglas, KT and Kikuchi, Y' (2002) Porphyrins and porphines inhibit the ribonuclease P reaction in vitro.* Nucleic Acids Res. Suppl. '**:111-2
Abstract	Porphyrin has been reported to bind to the T psi C stem of tRNA. This site is also recognized by ribonuclease P, which is essential and ubiquitous endoribonuclease responsible for the maturation of 5' ends of tRNA precursors. Thus, we investigated the effects of porphyrins on the in vitro reaction of ribonuclease P from Escherichia coli. The results showed that some of porphyrins inhibited the reaction more strongly than any other inhibitors reported so far. In addition to the benzimidazole inhibition that we have previously reported, these unusual substrate-binding inhibitions may provide new leads for the novel anti-bacterial reagent design.
Links	PubMed
Keywords	Endoribonucleases/antagonists & inhibitors; Endoribonucleases/metabolism; Enzyme Inhibitors/pharmacology; Escherichia coli Proteins; Porphyrins/chemistry; Porphyrins/pharmacology; RNA, Catalytic/antagonists & inhibitors; RNA, Catalytic/metabolism; Ribonuclease P
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