PMID:12867475
| Citation |
Kim, M, Huang, T and Miller, JH (2003) Competition between MutY and mismatch repair at A x C mispairs In vivo. J. Bacteriol. 185:4626-9 |
|---|---|
| Abstract |
We show that the MutY protein competes with the MutS-dependent mismatch repair system to process at least some A. C mispairs in vivo, converting them to G. C pairs. In the presence of an increased dCTP pool resulting from the loss of nucleotide diphosphate kinase, the frequency of A. T-->G. C transitions at a hot spot in the rpoB gene is 30-fold lower in a MutY-deficient derivative than in the wild type. |
| Links | |
| Keywords |
Adenosine Triphosphatases/genetics; Adenosine Triphosphatases/metabolism; Bacterial Proteins; Base Pair Mismatch; DNA Glycosylases; DNA Repair; DNA-Binding Proteins; DNA-Directed RNA Polymerases/genetics; DNA-Directed RNA Polymerases/metabolism; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; MutS DNA Mismatch-Binding Protein; Mutation; N-Glycosyl Hydrolases/genetics; N-Glycosyl Hydrolases/metabolism |
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