PMID:12754247
| Citation |
Tompkins, JD, Nelson, JL, Hazel, JC, Leugers, SL, Stumpf, JD and Foster, PL (2003) Error-prone polymerase, DNA polymerase IV, is responsible for transient hypermutation during adaptive mutation in Escherichia coli. J. Bacteriol. 185:3469-72 |
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| Abstract |
The frequencies of nonselected mutations among adaptive Lac(+) revertants of Escherichia coli strains with and without the error-prone DNA polymerase IV (Pol IV) were compared. This frequency was more than sevenfold lower in the Pol IV-defective strain than in the wild-type strain. Thus, the mutations that occur during hypermutation are due to Pol IV. |
| Links | |
| Keywords |
Adaptation, Physiological; Culture Media; DNA Polymerase beta/metabolism; Escherichia coli/enzymology; Escherichia coli/genetics; Escherichia coli/growth & development; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Lactose/metabolism; Mutation |
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