PMID:12743100
| Citation |
Vilar, JM, Guet, CC and Leibler, S (2003) Modeling network dynamics: the lac operon, a case study. J. Cell Biol. 161:471-6 |
|---|---|
| Abstract |
We use the lac operon in Escherichia coli as a prototype system to illustrate the current state, applicability, and limitations of modeling the dynamics of cellular networks. We integrate three different levels of description (molecular, cellular, and that of cell population) into a single model, which seems to capture many experimental aspects of the system. |
| Links |
PubMed PMC2172934 Online version:10.1083/jcb.200301125 |
| Keywords |
Animals; Computational Biology/methods; Computational Biology/trends; Escherichia coli/genetics; Escherichia coli/metabolism; Humans; Lac Operon/genetics; Lactose/genetics; Lactose/metabolism; Models, Biological; Nonlinear Dynamics |
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