PMID:12732300

Citation	Massé, E, Majdalani, N and Gottesman, S (2003) Regulatory roles for small RNAs in bacteria. Curr. Opin. Microbiol. 6:120-4
Abstract	Small RNAs can act to regulate both the synthesis of proteins, by affecting mRNA transcription, translation and stability, and the activity of specific proteins by binding to them. As a result of recent genome-wide screens, around 50 small RNAs have now been identified in Escherichia coli. These include many that require the RNA-binding protein Hfq for their activity; most of these RNAs act by pairing with their target mRNAs. Small RNAs can both positively and negatively regulate translation, can simultaneously regulate multiple mRNA targets, and can change the pattern of polarity within an operon.
Links	PubMed
Keywords	Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Escherichia coli/chemistry; Escherichia coli/genetics; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Gene Expression Regulation, Bacterial; Host Factor 1 Protein/genetics; Host Factor 1 Protein/metabolism; RNA, Bacterial/chemistry; RNA, Bacterial/isolation & purification; RNA, Bacterial/physiology; RNA, Untranslated/physiology; Sigma Factor/genetics; Sigma Factor/metabolism
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