PMID:12730188
| Citation |
Camara, JE, Skarstad, K and Crooke, E (2003) Controlled initiation of chromosomal replication in Escherichia coli requires functional Hda protein. J. Bacteriol. 185:3244-8 |
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| Abstract |
Regulatory inactivation of DnaA helps ensure that the Escherichia coli chromosome is replicated only once per cell cycle, through accelerated hydrolysis of active replication initiator ATP-DnaA to inactive ADP-DnaA. Analysis of deltahda strains revealed that the regulatory inactivation of DnaA component Hda is necessary for maintaining controlled initiation but not for cell growth or viability. |
| Links | |
| Keywords |
Adenosine Triphosphatases/genetics; Adenosine Triphosphatases/metabolism; Cell Division/genetics; Chromosomes, Bacterial; DNA Replication; DNA, Bacterial/genetics; DNA, Bacterial/metabolism; Escherichia coli/cytology; Escherichia coli/genetics; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Flow Cytometry; Mutation; Transduction, Genetic |
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