PMID:12718760

Citation	Handa, N and Kobayashi, I (2003) Accumulation of large non-circular forms of the chromosome in recombination-defective mutants of Escherichia coli. BMC Mol. Biol. 4:5
Abstract	Double-strand breakage of chromosomal DNA is obviously a serious threat to cells because various activities of the chromosome depend on its integrity. However, recent experiments suggest that such breakage may occur frequently during "normal" growth in various organisms - from bacteria through vertebrates, possibly through arrest of a replication fork at some endogenous DNA damage.
Links	PubMed PMC156651 Online version:10.1186/1471-2199-4-5
Keywords	Chromosome Breakage/genetics; Chromosomes, Bacterial/genetics; Culture Media/metabolism; Electrophoresis, Gel, Pulsed-Field/methods; Endodeoxyribonucleases/deficiency; Endodeoxyribonucleases/genetics; Escherichia coli/enzymology; Escherichia coli/genetics; Escherichia coli/growth & development; Escherichia coli Proteins; Exodeoxyribonuclease V; Exodeoxyribonucleases/deficiency; Exodeoxyribonucleases/genetics; Exodeoxyribonucleases/physiology; Mutation; Recombination, Genetic/genetics
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