PMID:12697336
| Citation |
Li, J, Deslouches, B, Cosloy, SD and Russell, CS (2003) A heme-deficient strain of Escherichia coli has a three-base pair deletion in a "hotspot" in hemA. Biochim. Biophys. Acta 1626:102-5 |
|---|---|
| Abstract |
The key regulatory step in heme biosynthesis in Escherichia coli is at the level of glutamyl-tRNA reductase (GTR), an enzyme which is encoded by hemA. A strain, HU227, with a spontaneous in-frame mutation in hemA has no GTR activity. The mutation is shown to be a three-base deletion at a "hotspot" in the gene. The amino acid sequence in this region is highly conserved. |
| Links | |
| Keywords |
Aldehyde Oxidoreductases/chemistry; Aldehyde Oxidoreductases/genetics; Amino Acid Sequence; Base Sequence; Conserved Sequence; Escherichia coli/enzymology; Heme/biosynthesis; Molecular Sequence Data; Sequence Deletion |
| edit table |
Significance
You can help EcoliWiki by summarizing why this paper is useful
Useful Materials and Methods
You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.
Annotations
<annotationlinks/>
EcoliWiki Links
Add links to pages that link here (e.g. gene, product, method pages)
References
See Help:References for how to manage references in EcoliWiki.
