PMID:12695322

Citation	King, OD, Foulger, RE, Dwight, SS, White, JV and Roth, FP (2003) Predicting gene function from patterns of annotation. Genome Res. 13:896-904
Abstract	The Gene Ontology (GO) Consortium has produced a controlled vocabulary for annotation of gene function that is used in many organism-specific gene annotation databases. This allows the prediction of gene function based on patterns of annotation. For example, if annotations for two attributes tend to occur together in a database, then a gene holding one attribute is likely to hold the other as well. We modeled the relationships among GO attributes with decision trees and Bayesian networks, using the annotations in the Saccharomyces Genome Database (SGD) and in FlyBase as training data. We tested the models using cross-validation, and we manually assessed 100 gene-attribute associations that were predicted by the models but that were not present in the SGD or FlyBase databases. Of the 100 manually assessed associations, 41 were judged to be true, and another 42 were judged to be plausible.
Links	PubMed PMC430892 Online version:10.1101/gr.440803
Keywords	Animals; Computational Biology/methods; Databases, Genetic/standards; Databases, Genetic/statistics & numerical data; Decision Trees; Drosophila melanogaster/genetics; Forecasting; Genes, Fungal/physiology; Genes, Insect/physiology; Genome; Genome, Fungal; Models, Genetic; Saccharomyces cerevisiae/genetics; Species Specificity; Terminology as Topic
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