PMID:12615853
| Citation |
El Zoeiby, A, Sanschagrin, F, Darveau, A, Brisson, JR and Levesque, RC (2003) Identification of novel inhibitors of Pseudomonas aeruginosa MurC enzyme derived from phage-displayed peptide libraries. J. Antimicrob. Chemother. 51:531-43 |
|---|---|
| Abstract |
The machinery of peptidoglycan biosynthesis is an ideal site at which to look for novel antimicrobial targets. Phage display was used to develop novel peptide inhibitors for MurC, an essential enzyme involved in the early steps of biosynthesis of peptidoglycan monomer. |
| Links | |
| Keywords |
Amino Acid Sequence; Bacteriophage M13; Drug Delivery Systems/methods; Enzyme Inhibitors/pharmacology; Enzyme Inhibitors/therapeutic use; Escherichia coli/drug effects; Escherichia coli/enzymology; Escherichia coli/genetics; Escherichia coli/virology; Molecular Sequence Data; Peptide Library; Peptide Synthases/antagonists & inhibitors; Peptide Synthases/genetics; Pseudomonas aeruginosa/drug effects; Pseudomonas aeruginosa/genetics; Sequence Analysis, Protein/methods |
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