PMID:12588096
| Citation |
Modrzewska, M, Karpiński, P, Grudniak, A and Wolska, KI (2002) Effect of null mutations in dnaK and dnaJ genes on conjugational DNA transfer, proteolysis and novobiocin susceptibility of Escherichia coli. Acta Microbiol. Pol. 51:217-24 |
|---|---|
| Abstract |
Escherichia coli null dnaJ and dnaKdnaJ mutants, when introduced to Hfr donor, impair its ability to DNA transfer during conjugation. The additive effect of both mutations was shown. Lack of DnaK and DnaJ chaperones also decrease the extent of proteolysis in mutant strains. This effect is seen only at 42 degrees C. The influence of double dnaKdnaJ deletion but not single dnaJ deletion on novobiocin susceptibility was also demonstrated. |
| Links | |
| Keywords |
Anti-Bacterial Agents/pharmacology; Canavanine/pharmacology; Conjugation, Genetic/drug effects; Conjugation, Genetic/genetics; Conjugation, Genetic/physiology; Escherichia coli/drug effects; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli Proteins; HSP40 Heat-Shock Proteins; HSP70 Heat-Shock Proteins/genetics; HSP70 Heat-Shock Proteins/metabolism; Heat-Shock Proteins/genetics; Heat-Shock Proteins/metabolism; Microbial Sensitivity Tests; Molecular Chaperones/genetics; Molecular Chaperones/metabolism; Mutation; Novobiocin/pharmacology |
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