PMID:12581356
| Citation |
Fröderberg, L, Houben, E, Samuelson, JC, Chen, M, Park, SK, Phillips, GJ, Dalbey, R, Luirink, J and De Gier, JW (2003) Versatility of inner membrane protein biogenesis in Escherichia coli. Mol. Microbiol. 47:1015-27 |
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| Abstract |
To further our understanding of inner membrane protein (IMP) biogenesis in Escherichia coli, we have accomplished the widest in vivo IMP assembly screen so far. The biogenesis of a set of model IMPs covering most IMP structures possible has been studied in a variety of signal recognition particle (SRP), Sec and YidC mutant strains. We show that the assembly of the complete set of model IMPs is assisted (i.e. requires the aid of proteinaceous factors), and that the requirements for assembly of the model IMPs into the inner membrane differ significantly from each other. This indicates that IMP assembly is much more versatile than previously thought. |
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| Keywords |
Adenosine Triphosphatases/metabolism; Bacterial Proteins/biosynthesis; Bacterial Proteins/genetics; Base Sequence; Cell Membrane/chemistry; Cell Membrane/metabolism; DNA, Bacterial/genetics; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli Proteins/biosynthesis; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Membrane Proteins/biosynthesis; Membrane Proteins/genetics; Membrane Transport Proteins/metabolism; Models, Biological; Mutation; Signal Recognition Particle/biosynthesis; Signal Recognition Particle/genetics |
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