PMID:12568584
| Citation |
He, C, Wei, H and Verdine, GL (2003) Converting the sacrificial DNA repair protein N-ada into a catalytic methyl phosphotriester repair enzyme. J. Am. Chem. Soc. 125:1450-1 |
|---|---|
| Abstract |
Mutation of the active-site residue Cys38 of N-Ada converts it from a sacrificial DNA repair protein to an enzyme that uses methanethiol as an external sacrificial reagent to repair DNA methyl phosphotriesters catalytically. |
| Links |
PubMed Online version:10.1021/ja028046a |
| Keywords |
Bacterial Proteins/chemistry; Bacterial Proteins/metabolism; Catalysis; DNA Ligases/chemistry; DNA Ligases/metabolism; DNA Repair; Escherichia coli Proteins; O(6)-Methylguanine-DNA Methyltransferase; Organophosphates/chemistry; Organophosphates/metabolism; Protein Structure, Tertiary; Transcription Factors |
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