PMID:12531178
| Citation |
Mansky, LM (2002) HIV mutagenesis and the evolution of antiretroviral drug resistance. Drug Resist. Updat. 5:219-23 |
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| Abstract |
The development of antiretroviral drug resistance is a major threat to the effective treatment of human immunodeficiency virus type 1 (HIV-1) infection. Drug treatment failure is associated with accumulation of drug resistance mutations and the evolution of drug resistance. Studies from microbial systems provide evidence for a correlation between drug resistance development and increased pathogen mutation rates. Recent studies with HIV-1 have shown that drugs targeted against reverse transcriptase (RT) as well as drug-resistant RT can increase HIV-1 mutation frequencies. Furthermore, combinations of drug and drug-resistant RT have been found to increase virus mutation frequencies in a multiplicative manner. The correlation of increased HIV-1 mutation rates with the evolution of antiretroviral drug resistance indicates that drug failure could increase the likelihood of further resistance evolving from subsequent drug regimens. |
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| Keywords |
Anti-HIV Agents/pharmacology; Antiretroviral Therapy, Highly Active; Drug Resistance, Viral; HIV Infections/drug therapy; HIV Infections/virology; HIV-1/drug effects; HIV-1/genetics; Humans; Mutagenesis/drug effects |
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