PMID:12498704
| Citation |
Jiricny, J (2002) DNA repair: bioinformatics helps reverse methylation damage. Curr. Biol. 12:R846-8 |
|---|---|
| Abstract |
Recent work has uncovered a novel DNA repair enzyme: the AlkB protein of Escherichia coli, which oxidises the methyl groups of 1-methyladenine and 3-methylcytosine to hydroxymethyl moieties; the oxidised groups are subsequently released as formaldehyde, regenerating the unmodified bases. |
| Links | |
| Keywords |
Adenine/analogs & derivatives; Adenine/metabolism; Computational Biology/methods; Cytosine/analogs & derivatives; Cytosine/metabolism; DNA Methylation; DNA Repair/physiology; Escherichia coli/genetics; Escherichia coli Proteins/physiology; Mixed Function Oxygenases/physiology |
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