PMID:12464173
| Citation |
Dreyfus, M and Régnier, P (2002) The poly(A) tail of mRNAs: bodyguard in eukaryotes, scavenger in bacteria. Cell 111:611-3 |
|---|---|
| Abstract |
In eukaryotes, poly(A) tails usually act as stabilizers of intact mRNAs, whereas in E. coli they serve to accelerate the destruction of fragments. The mechanisms underlying these contrasting effects of the same RNA modification are discussed. |
| Links | |
| Keywords |
Cell Compartmentation; Cell Nucleus/metabolism; Cytoplasm/metabolism; Endoribonucleases/metabolism; Escherichia coli/metabolism; Eukaryotic Cells/metabolism; Exoribonucleases/metabolism; Kinetics; Models, Biological; Poly A/genetics; Poly A/metabolism; Poly(A)-Binding Proteins/metabolism; RNA Processing, Post-Transcriptional; RNA, Bacterial/metabolism; RNA, Messenger/metabolism |
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