PMID:12464172
| Citation |
Georgiou, G (2002) How to flip the (redox) switch. Cell 111:607-10 |
|---|---|
| Abstract |
Redox-sensitive transcription factors such as the E. coli OxyR and S. cerevisiae Yap1, are activated by conformational changes that stem from the post-translational modification of reactive protein thiols. Recent studies provide new insights on how different agents that cause redox stress mediate the activation of transcription through distinct and specific pathways. |
| Links | |
| Keywords |
Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Cysteine/chemistry; Cysteine/metabolism; DNA-Binding Proteins/metabolism; Disulfides/chemistry; Escherichia coli/chemistry; Escherichia coli/genetics; Escherichia coli/metabolism; Glutathione Peroxidase/chemistry; Glutathione Peroxidase/drug effects; Glutathione Peroxidase/metabolism; Hydrogen Peroxide/metabolism; Hydrogen Peroxide/pharmacology; Models, Biological; Mutation; Oxidation-Reduction; Oxidative Stress; Protein Conformation; Protein Processing, Post-Translational; Reactive Oxygen Species/metabolism; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/metabolism; Transcription Factors/genetics; Transcription Factors/metabolism; Transcriptional Activation |
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