PMID:12452432
| Citation |
Chen, M, Xie, K, Jiang, F, Yi, L and Dalbey, RE (2002) YidC, a newly defined evolutionarily conserved protein, mediates membrane protein assembly in bacteria. Biol. Chem. 383:1565-72 |
|---|---|
| Abstract |
Membranes contain proteins that catalyze a variety of reactions, which lead to the selective permeability of the membrane. For membrane proteins to function as receptors, transporters, channels, and ATPases, they must be targeted to their correct membrane and inserted into the lipid bilayer. Recently, a new membrane component called YidC was discovered that mediates the insertion of proteins into membranes in bacteria. YidC homologs also exist in mitochondria and chloroplasts. Depletion of YidC from the cell interferes with the insertion of membrane proteins that insert both dependent and independent of the SecYEG/SecDFYajC machinery. YidC directly interacts with membrane proteins during the membrane protein insertion process and assists in the folding of the hydrophobic regions into the membrane bilayer. The chloroplast and bacterial YidC homologs are truly functional homologs because the chloroplast homolog Alb3 functionally complements the bacterial YidC depletion strain. The role of YidC in the membrane insertion pathway will be reviewed. |
| Links |
PubMed Online version:10.1515/BC.2002.176 |
| Keywords |
Adenosine Triphosphatases/physiology; Bacterial Proteins/chemistry; Bacterial Proteins/genetics; Bacterial Proteins/physiology; Biological Transport; Conserved Sequence; Escherichia coli Proteins/physiology; Evolution, Molecular; Intracellular Membranes/chemistry; Intracellular Membranes/metabolism; Membrane Proteins/chemistry; Membrane Proteins/metabolism; Membrane Transport Proteins/physiology; Models, Biological |
| edit table |
Significance
You can help EcoliWiki by summarizing why this paper is useful
Useful Materials and Methods
You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.
Annotations
<annotationlinks/>
EcoliWiki Links
Add links to pages that link here (e.g. gene, product, method pages)
References
See Help:References for how to manage references in EcoliWiki.