PMID:12429059
| Citation |
Zheng, Y, Roberts, RJ and Kasif, S (2002) Genomic functional annotation using co-evolution profiles of gene clusters. Genome Biol. 3:RESEARCH0060 |
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| Abstract |
The current speed of sequencing already exceeds the capability of annotation, creating a potential bottleneck. A large proportion of the genes in microbial genomes remains uncharacterized. Here we propose a new method for functional annotation using the conservation patterns of gene clusters. If several gene clusters show the same coevolution pattern across different genomes it is reasonable to infer they are functionally related. The gene cluster phylogenetic profile integrates chromosomal proximity information and phylogenetic profile information and allows us to infer functional dependences between the gene clusters even at great distance on the chromosome. |
| Links | |
| Keywords |
Alleles; Chromosomes, Bacterial/genetics; Escherichia coli/genetics; Evolution, Molecular; Genes, Bacterial/physiology; Genome, Bacterial; Models, Statistical; Multigene Family/genetics; Multigene Family/physiology; Phylogeny |
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