PMID:12405345
| Citation |
Betton, JM, Phichith, D and Hunke, S (2002) Folding and aggregation of export-defective mutants of the maltose-binding protein. Res. Microbiol. 153:399-404 |
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| Abstract |
We previously characterized a defective-folding variant of the periplasmic maltose-binding protein, MalE31. To examine the alternative folding pathways open to the MalE31 precursor, we have analyzed the cellular fates of this aggregation-prone protein carrying altered signal sequences. Our results are most easily interpreted by a kinetic competition between exportation, folding, and degradation. |
| Links | |
| Keywords |
Biological Transport; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli/physiology; Escherichia coli Proteins/chemistry; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Genetic Variation; Heat-Shock Proteins/metabolism; Heat-Shock Response; Mutagenesis, Site-Directed; Mutation; Periplasmic Binding Proteins/chemistry; Periplasmic Binding Proteins/genetics; Periplasmic Binding Proteins/metabolism; Protein Conformation; Protein Folding; Protein Sorting Signals/genetics; Subcellular Fractions/metabolism |
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