PMID:12226862

Citation	Giona, M and Adrover, A (2002) Modified model for the regulation of the tryptophan operon in Escherichia coli. Biotechnol. Bioeng. 80:297-304
Abstract	This article proposes a modification of the model developed by Sinha (1988) and Sen and Liu (1990) for the regulation dynamics of the tryptophan operon in E. coli based on a consistent overall balance of the agent repressing the mRNA transcription. The dynamics of the model are analyzed by means of continuation techniques and the influence of periodic fluctuations in the intracellular demand for tryptophan is addressed. The analysis provides deeper insight into the dynamics of this operon system and the results obtained may be a useful starting point for the optimization of tryptophan yield in bacterial cultures.
Links	PubMed Online version:10.1002/bit.10373
Keywords	Bacterial Proteins; Computer Simulation; Escherichia coli/genetics; Escherichia coli/metabolism; Gene Expression Regulation, Bacterial; Genetic Engineering; Models, Chemical; Models, Genetic; Operon/genetics; Periodicity; Quality Control; Repressor Proteins/genetics; Repressor Proteins/metabolism; Sensitivity and Specificity; Stochastic Processes; Tryptophan/biosynthesis; Tryptophan/genetics
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