PMID:12206460
| Citation |
Fontecave, M, Mulliez, E and Logan, DT (2002) Deoxyribonucleotide synthesis in anaerobic microorganisms: the class III ribonucleotide reductase. Prog. Nucleic Acid Res. Mol. Biol. 72:95-127 |
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| Abstract |
For growth under oxygen-free atmosphere, some strict or facultative anaerobes depend on a class III ribonucleotide reductase for the synthesis of deoxyribonucleotides, the DNA precursors. Prototypes for this class of enzymes are ribonucleotide reductases from Escherichia coli and bacteriophage T4. This review article describes their structural and mechanistic properties as well as their complex allosteric regulation. Their evolutionnary relationship to class I and class II ribonucleotide reductases is also discussed. |
| Links | |
| Keywords |
Amino Acid Sequence; Anaerobiosis; Bacteria, Anaerobic; Bacterial Proteins; DNA; Deoxyribonucleotides/biosynthesis; Escherichia coli Proteins; Gene Expression Regulation; Molecular Sequence Data; RNA; Ribonucleotide Reductases/genetics; Ribonucleotide Reductases/metabolism; Viral Proteins/genetics; Viral Proteins/metabolism |
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