PMID:12169561
| Citation |
Höhl, M, Kurtz, S and Ohlebusch, E (2002) Efficient multiple genome alignment. Bioinformatics 18 Suppl 1:S312-20 |
|---|---|
| Abstract |
MOTIVATION: To allow a direct comparison of the genomic DNA sequences of sufficiently similar organisms, there is an urgent need for software tools that can align more than two genomic sequences. RESULTS: We developed new algorithms and a software tool 'Multiple Genome Aligner' (MGA for short) that efficiently computes multiple genome alignments of large, closely related DNA sequences. For example, it can align 85% percent of the complete genomes of six human adenoviruses (average length 35305 bp.) in 159 seconds. An alignment of 74% of the complete genomes of three of strains of E. coli (lengths: 5528445; 5498450; 4639221 approximately bp.) is produced in 30 minutes. |
| Links | |
| Keywords |
Algorithms; Animals; Base Sequence; Chromosome Mapping/methods; Evolution, Molecular; Gene Expression Profiling/methods; Humans; Molecular Sequence Data; Phylogeny; Sequence Alignment/methods; Sequence Analysis, DNA/methods; Sequence Homology, Nucleic Acid; Software |
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