PMID:12142437
| Citation |
Hutchings, MI, Mandhana, N and Spiro, S (2002) The NorR protein of Escherichia coli activates expression of the flavorubredoxin gene norV in response to reactive nitrogen species. J. Bacteriol. 184:4640-3 |
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| Abstract |
The Escherichia coli norVW genes encode a flavorubredoxin and NADH:(flavo)rubredoxin reductase, respectively, which are involved in nitric oxide detoxification under anaerobic growth conditions. Here it is shown that the norVW genes also have a role in protection against reactive nitrogen intermediates generated from nitroprusside. Transcription from the norV promoter is activated by the presence of nitroprusside in the growth medium; activation requires the product of a divergently transcribed regulatory gene, norR. |
| Links | |
| Keywords |
Base Sequence; DNA, Intergenic/genetics; Escherichia coli/enzymology; Escherichia coli/genetics; Escherichia coli Proteins/genetics; Escherichia coli Proteins/metabolism; Gene Expression Regulation, Bacterial; Gene Expression Regulation, Enzymologic; Molecular Sequence Data; NADH, NADPH Oxidoreductases/genetics; NADH, NADPH Oxidoreductases/metabolism; Nitric Oxide/metabolism; Phenotype; Promoter Regions, Genetic/genetics; Reactive Nitrogen Species/metabolism; Transcription Factors/genetics; Transcription Factors/metabolism |
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