PMID:12110601

Citation	Bidnenko, V, Ehrlich, SD and Michel, B (2002) Replication fork collapse at replication terminator sequences. EMBO J. 21:3898-907
Abstract	Replication fork arrest is a source of genome re arrangements, and the recombinogenic properties of blocked forks are likely to depend on the cause of blockage. Here we study the fate of replication forks blocked at natural replication arrest sites. For this purpose, Escherichia coli replication terminator sequences Ter were placed at ectopic positions on the bacterial chromosome. The resulting strain requires recombinational repair for viability, but replication forks blocked at Ter are not broken. Linear DNA molecules are formed upon arrival of a second round of replication forks that copy the DNA strands of the first blocked forks to the end. A model that accounts for the requirement for homologous recombination for viability in spite of the lack of chromosome breakage is proposed. This work shows that natural and accidental replication arrests sites are processed differently.
Links	PubMed PMC126115 Online version:10.1093/emboj/cdf369
Keywords	Base Sequence; DNA Replication; DNA, Bacterial/genetics; Escherichia coli/genetics; Terminator Regions, Genetic
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