PMID:12081643
| Citation |
Shimohata, N, Chiba, S, Saikawa, N, Ito, K and Akiyama, Y (2002) The Cpx stress response system of Escherichia coli senses plasma membrane proteins and controls HtpX, a membrane protease with a cytosolic active site. Genes Cells 7:653-62 |
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| Abstract |
The abnormal accumulation of misfolded proteins outside the plasma (cytoplasmic or inner) membrane up-regulates the synthesis of a class of envelope-localized catalysts of protein folding and degradation. The pathway for this transmembrane signalling is mediated by the CpxR-CpxA two-component phospho-relay mechanism. |
| Links | |
| Keywords |
ATP-Dependent Proteases; Bacterial Proteins/metabolism; Bacterial Proteins/physiology; Binding Sites; Cytosol/metabolism; Escherichia coli/enzymology; Escherichia coli/physiology; Escherichia coli Proteins; Heat-Shock Proteins/metabolism; Membrane Proteins/metabolism; Metalloendopeptidases/metabolism |
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