PMID:12057973

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Citation

Charpentier, X, Chalut, C, Rémy, MH and Masson, JM (2002) Penicillin-binding proteins 1a and 1b form independent dimers in Escherichia coli. J. Bacteriol. 184:3749-52

Abstract

We report here that PBP1a can dimerize but does not interact with PBP1b to form PBP1a/PBP1b heterodimers in Escherichia coli. These findings support the idea of a relevant involvement of dimerization of both PBP1a and PBP1b during murein synthesis and suggest the existence of different peptidoglycan synthesis complexes.

Links

PubMed PMC135119

Keywords

Bacterial Proteins; Carrier Proteins; Cloning, Molecular; Dimerization; Electrophoresis, Polyacrylamide Gel; Escherichia coli/genetics; Escherichia coli/metabolism; Escherichia coli Proteins; Hexosyltransferases/genetics; Hexosyltransferases/metabolism; Multienzyme Complexes/genetics; Multienzyme Complexes/metabolism; Muramoylpentapeptide Carboxypeptidase; Penicillin-Binding Proteins; Peptidoglycan Glycosyltransferase; Peptidyl Transferases/genetics; Peptidyl Transferases/metabolism; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Serine-Type D-Ala-D-Ala Carboxypeptidase

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