PMID:12052558

Citation	Corona-Izquierdo, FP and Membrillo-Hernández, J (2002) A mutation in rpoS enhances biofilm formation in Escherichia coli during exponential phase of growth. FEMS Microbiol. Lett. 211:105-10
Abstract	Biofilm formation in Escherichia coli is a process that involves slow growth and stress conditions where several molecular signals and growth phase regulated genes are involved. Here we show that rpoS mutant strains (defective in the stress regulator sigma(S)) exhibit an increased production of biofilm, especially in the exponential phase of growth. Our results indicate that rpoS mutants produce an extracellular factor that promotes the production of biofilm during the exponential phase of growth. Thus, RpoS plays an important role in the regulation of the amount and initiation of biofilm formation in E. coli.
Links	PubMed
Keywords	Bacterial Proteins/genetics; Biofilms/drug effects; Biofilms/growth & development; Biological Factors/analysis; Biological Factors/pharmacology; Culture Media, Conditioned/chemistry; Escherichia coli/classification; Escherichia coli/drug effects; Escherichia coli/genetics; Escherichia coli/growth & development; Extracellular Space/chemistry; Genes, Reporter/genetics; Mutation/genetics; Sigma Factor/genetics; beta-Galactosidase/genetics
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