PMID:12047352
| Citation |
Ueda, K, Yamamoto, Y, Ogawa, K, Abo, T, Inokuchi, H and Aiba, H (2002) Bacterial SsrA system plays a role in coping with unwanted translational readthrough caused by suppressor tRNAs. Genes Cells 7:509-19 |
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| Abstract |
Bacterial SsrA RNA (also known as tmRNA or 10Sa RNA) mediates the addition of a short peptide tag to the C-terminus of the nascent polypeptide when a ribosome is stalled at the 3' end of an mRNA lacking a stop codon. This process, called trans-translation, rescues the stalled ribosome and ensures degradation of tagged polypeptides by ATP-dependent proteases. To fully understand the physiological roles of SsrA RNA, it is essential to know how endogenous mRNA targets for the SsrA system are generated in cells. The aim of the present study is to examine how translational readthrough by suppressor tRNAs affects trans-translation in Escherichia coli. |
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| Keywords |
Amino Acid Sequence; Base Sequence; DNA, Bacterial; Escherichia coli/genetics; Escherichia coli/physiology; Gene Expression Regulation, Bacterial; Molecular Sequence Data; Protein Biosynthesis; RNA, Bacterial/physiology; RNA, Transfer/physiology; Receptors, Cyclic AMP/genetics |
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