PMID:12007989
| Citation |
Champoux, JJ (2002) A first view of the structure of a type IA topoisomerase with bound DNA. Trends Pharmacol. Sci. 23:199-201 |
|---|---|
| Abstract |
The first crystal structure of a type IA topoisomerase with bound DNA has been solved. The structure of Escherichia coli topoisomerase III provides key insights regarding the catalytic mechanism and the conformational changes that accompany DNA binding, and enhances our understanding of how topoisomerases control DNA topology in the cell. |
| Links | |
| Keywords |
Catalysis; DNA/metabolism; DNA Topoisomerases, Type I/chemistry; DNA Topoisomerases, Type I/metabolism; Escherichia coli/enzymology; Protein Conformation |
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