PMID:11934618
| Citation |
Cronan, JE Jr (2002) Phospholipid modifications in bacteria. Curr. Opin. Microbiol. 5:202-5 |
|---|---|
| Abstract |
Many bacteria alter the acyl chains of their membrane phospholipids in response to changing environmental conditions. Two of these modifications are reviewed: cis-->trans isomerization and cyclopropanation of double bonds. The isomerization reaction is now known to be catalyzed by a periplasmic protein that contains a covalently bound heme. Cyclopropanation has been shown to play a role in Mycobacterium tuberculosis pathogenesis and, in Escherichia coli, plays an important role in resistance to acidic conditions. |
| Links | |
| Keywords |
Adaptation, Physiological; Bacteria/metabolism; Cyclopropanes/chemistry; Cyclopropanes/metabolism; Escherichia coli/metabolism; Fatty Acids/chemistry; Fatty Acids/metabolism; Isomerism; Mycobacterium tuberculosis/metabolism; Mycobacterium tuberculosis/pathogenicity; Phospholipids/chemistry; Phospholipids/metabolism |
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