PMID:11909526
| Citation |
Ramakrishnan, V (2002) Ribosome structure and the mechanism of translation. Cell 108:557-72 |
|---|---|
| Abstract |
The publication of crystal structures of the 50S and 30S ribosomal subunits and the intact 70S ribosome is revolutionizing our understanding of protein synthesis. This review is an attempt to correlate the structures with biochemical and genetic data to identify the gaps and limits in our current knowledge of the mechanisms involved in translation. |
| Links | |
| Keywords |
Bacteria/genetics; Bacterial Proteins/metabolism; Models, Genetic; Models, Molecular; Peptide Chain Elongation, Translational; Peptide Elongation Factor Tu/metabolism; Peptide Initiation Factors/metabolism; Peptide Termination Factors/metabolism; Peptidyl Transferases/metabolism; Protein Biosynthesis; Protein Structure, Quaternary; Protein Subunits; RNA, Messenger/metabolism; Ribosomes/chemistry; Ribosomes/metabolism |
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