PMID:11902440
| Citation |
Teplyakov, A, Leriche, C, Obmolova, G, Badet, B and Badet-Denisot, MA (2002) From Lobry de Bruyn to enzyme-catalyzed ammonia channelling: molecular studies of D-glucosamine-6P synthase. Nat Prod Rep 19:60-9 |
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| Abstract |
This review summarizes the state of knowledge on D-glucosamine-6P synthesis catalyzed by glucosamine-6P synthase. The mechanisms of L-glutamine hydrolysis, ammonia transfer and fructose-6P conversion into D-glucosamine-6P are analyzed with the E. coli enzyme in light of recent X-ray structures. With 92 references this paper covers the literature up to June 2001 and emphasizes the potential implication of the mammalian glucosamine-6P synthase in type 2 diabetes. |
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| Keywords |
Ammonia/metabolism; Animals; Catalysis; Crystallography, X-Ray; Diabetes Mellitus, Type 2/enzymology; Escherichia coli/enzymology; Fungi/enzymology; Glucosamine/analogs & derivatives; Glucosamine/biosynthesis; Glucose/chemistry; Glucose/metabolism; Glucose-6-Phosphate/analogs & derivatives; Glucose-6-Phosphate/biosynthesis; Glutamine/chemistry; Glutamine/metabolism; Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)/chemistry; Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)/metabolism; Humans; Hydrolysis; Mice; Molecular Structure; Nitrogen/chemistry; Nitrogen/metabolism; Protein Conformation; Rats; Structure-Activity Relationship |
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