PMID:11804580

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Citation

Donahue, WF and Jarrell, KA (2002) A BLAST from the past: ancient origin of human Sm proteins. Mol. Cell 9:7-8

Abstract

In this issue of Molecular Cell, Zhang et al. and Møller et al. independently report studies of the E. coli Hfq protein, revealing significant sequence similarities with human Sm proteins. Their findings suggest that Hfq, and the Sm and Sm-like (Lsm) proteins, may function in stabilizing interactions between RNA molecules.

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Keywords

Autoantigens/genetics; Autoantigens/metabolism; Carrier Proteins/genetics; Carrier Proteins/metabolism; Escherichia coli; Escherichia coli Proteins; Evolution, Molecular; Host Factor 1 Protein; Humans; Integration Host Factors; Protein Binding; RNA/genetics; RNA/metabolism; RNA-Binding Proteins/genetics; RNA-Binding Proteins/metabolism; Repressor Proteins/genetics; Repressor Proteins/metabolism; Ribonucleoproteins, Small Nuclear/genetics; Ribonucleoproteins, Small Nuclear/metabolism; Transcription Factors/genetics; Transcription Factors/metabolism; snRNP Core Proteins

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