PMID:11786251
| Citation |
Diez, AA, Tunlid, A and Nyström, T (2002) The Escherichia coli ftsK1 mutation attenuates the induction of sigma(S)-dependent genes upon transition to stationary phase. FEMS Microbiol. Lett. 206:19-23 |
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| Abstract |
A mutation in the cell division gene ftsK causes super-induction of sigma(70)-dependent stress defense genes, such as uspA, during entry of cells into stationary phase. In contrast, we report here that stationary phase induction of sigma(S)-dependent genes, uspB and cfa, is attenuated and that sigma(S) accumulates at a lower rate in ftsK1 cells. Ectopic overexpression of rpoS restored induction of the rpoS regulon in the ftsK mutant, as did a deletion in the recA gene. Thus, a mutation in the cell division gene, ftsK, uncouples the otherwise coordinated induction of sigma(S)-dependent genes and the universal stress response gene, uspA, during entry into stationary phase. |
| Links | |
| Keywords |
Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Cyclopropanes/metabolism; Escherichia coli/genetics; Escherichia coli/growth & development; Escherichia coli Proteins; Fatty Acids/metabolism; Gene Deletion; Gene Expression Regulation, Bacterial; Membrane Proteins/genetics; Membrane Proteins/metabolism; Mutation; Rec A Recombinases/genetics; Sigma Factor/genetics; Sigma Factor/metabolism |
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