PMID:11717515
| Citation |
Sun, T, Nukaga, M, Mayama, K, Crichlow, GV, Kuzin, AP and Knox, JR (2001) Crystallization and preliminary X-ray study of OXA-1, a class D beta-lactamase. Acta Crystallogr. D Biol. Crystallogr. 57:1912-4 |
|---|---|
| Abstract |
The Escherichia coli OXA-1 oxacillinase, a beta-lactamase which provides resistance to beta-lactam antibiotics (penicillins and cephalosporins), has been crystallized. A member of the class D family of serine beta-lactamases, OXA-1 is especially active against the penicillins oxacillin and cloxacillin and is now found in 10% of E. coli clinical isolates. Crystals grown from PEG 8000 at pH 7.5 diffract to 1.5 A resolution at 100 K and have space group P1 (Z = 2), with unit-cell parameters a = 36.0, b = 51.6, c = 72.9 A, alpha = 70.2, beta = 84.1, gamma = 81.5 degrees. |
| Links | |
| Keywords |
Crystallization; Crystallography, X-Ray; Escherichia coli/enzymology; Protein Conformation; Uranium/chemistry; beta-Lactamases/chemistry |
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