PMID:11695827
| Citation |
Steuber, J (2001) The Na+-translocating NADH:quinone oxidoreductase (NDH I) from Klebsiella pneumoniae and Escherichia coli: implications for the mechanism of redox-driven cation translocation by complex I. J. Bioenerg. Biomembr. 33:179-86 |
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| Abstract |
Eukaryotic complex I integrated into the respiratory chain transports at least 4 H+ per NADH oxidized. Recent results indicate that the cation selectivity is altered to Na+ in complex I (NDH I) isolated from the enterobacteria Escherichia coli and Klebsiella pneumoniae. A sequence analysis illustrates the characteristic differences of the enterobacterial, Na+-translocating NDH I compared to the H+-translocating complex I from mitochondria. Special attention is given to the membranous NuoL (ND5, Nqo12) subunits that possess striking sequence similarities to secondary Na+/H+ antiporters and are proposed to participate in Na+ transport. A model of redox-linked Na+ (or H+) transport by complex I is discussed based on the ion-pair formation of a negatively charged ubisemiquinone anion with a positively charged Na+ (or H+). |
| Links | |
| Keywords |
Amino Acid Sequence; Electron Transport; Electron Transport Complex I; Escherichia coli/enzymology; Escherichia coli/genetics; Genes, Bacterial; Ion Transport; Klebsiella pneumoniae/enzymology; Klebsiella pneumoniae/genetics; Models, Biological; Molecular Sequence Data; NADH, NADPH Oxidoreductases/chemistry; NADH, NADPH Oxidoreductases/genetics; NADH, NADPH Oxidoreductases/metabolism; Operon; Oxidation-Reduction; Protein Subunits; Sequence Homology, Amino Acid; Sodium/metabolism; Sodium-Hydrogen Antiporter/metabolism |
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