PMID:11549452
| Citation |
Husain, A, Chen, S, Wilson, DB and Ganem, B (2001) A selective inhibitor of Escherichia coli prephenate dehydratase. Bioorg. Med. Chem. Lett. 11:2485-8 |
|---|---|
| Abstract |
To identify selective prephenate dehydratase (PDT) inhibitors, a series of substituted biphenic acid derivatives was synthesized using the Ullmann reaction. Screening experiments identified 18 as a promising new PDT inhibitor. |
| Links | |
| Keywords |
Chorismate Mutase/antagonists & inhibitors; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/pharmacology; Escherichia coli/enzymology; Inhibitory Concentration 50; Nitrobenzoates/chemistry; Nitrobenzoates/pharmacology; Prephenate Dehydratase/antagonists & inhibitors; Structure-Activity Relationship |
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