PMID:11514139
| Citation |
Heerding, DA, Chan, G, DeWolf, WE, Fosberry, AP, Janson, CA, Jaworski, DD, McManus, E, Miller, WH, Moore, TD, Payne, DJ, Qiu, X, Rittenhouse, SF, Slater-Radosti, C, Smith, W, Takata, DT, Vaidya, KS, Yuan, CC and Huffman, WF (2001) 1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI). Bioorg. Med. Chem. Lett. 11:2061-5 |
|---|---|
| Abstract |
1,4-Disubstituted imidazole inhibitors of Staphylococcus aureus and Escherichia coli enoyl acyl carrier protein reductase (FabI) have been identified. Crystal structure data shows the inhibitor 1 bound in the enzyme active site of E. coli FabI. |
| Links | |
| Keywords |
Anti-Bacterial Agents/chemical synthesis; Anti-Bacterial Agents/chemistry; Anti-Bacterial Agents/pharmacology; Enoyl-(Acyl-Carrier-Protein) Reductase (NADH); Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/pharmacology; Escherichia coli/drug effects; Escherichia coli Proteins; Fatty Acid Synthetase Complex, Type II; Imidazoles/chemical synthesis; Imidazoles/chemistry; Imidazoles/pharmacology; Microbial Sensitivity Tests; Oxidoreductases/antagonists & inhibitors; Staphylococcus aureus/drug effects |
| edit table |
Significance
You can help EcoliWiki by summarizing why this paper is useful
Useful Materials and Methods
You can help Ecoliwiki by describing the useful materials (strains, plasmids, antibodies, etc) described in this paper.
Annotations
<annotationlinks/>
EcoliWiki Links
Add links to pages that link here (e.g. gene, product, method pages)
References
See Help:References for how to manage references in EcoliWiki.