PMID:11485421

Citation	Zhu, T, Phalakornkule, C, Koepsel, RR, Domach, MM and Ataai, MM Cell growth and by-product formation in a pyruvate kinase mutant of E. coli. Biotechnol. Prog. 17:624-8
Abstract	In this paper, we report on the analysis of acid formation in an E. coli pyk mutant. The results demonstrate that acid formation is insignificant for both the wild-type and the mutant at low glucose concentrations. However, at relatively high glucose concentrations, acid formation remains very low for the mutant but is significant for the wild-type. This substantial reduction in acids is accompanied by an increase in CO(2) production. Moreover, unlike the B. subtilis pyk mutant, the E. coli pyk mutant did not show a substantial increase in the PEP pool.
Links	PubMed Online version:10.1021/bp0100575
Keywords	Acids/metabolism; Bacillus subtilis/genetics; Bacillus subtilis/metabolism; Carbon Dioxide/metabolism; Cell Division/genetics; Escherichia coli/genetics; Escherichia coli/metabolism; Glucose/metabolism; Mutation; Phosphoenolpyruvate/metabolism; Pyruvate Kinase/genetics; Pyruvate Kinase/metabolism
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