PMID:11452124

Citation	Baudouin-Cornu, P, Surdin-Kerjan, Y, Marlière, P and Thomas, D (2001) Molecular evolution of protein atomic composition. Science 293:297-300
Abstract	Living organisms encounter various growth conditions in their habitats, raising the question of whether ecological fluctuations could alter biological macromolecules. The advent of complete genome sequences and the characterization of whole metabolic pathways allowed us to search for such ecological imprints. Significant correlations between atomic composition and metabolic function were found in sulfur- and carbon-assimilatory enzymes, which appear depleted in sulfur and carbon, respectively, in both the bacterium Escherichia coli and the eukaryote Saccharomyces cerevisiae. In addition to genetic instructions, genomic data thus also provide paleontological records of environmental nutrient availability and of metabolic costs.
Links	PubMed Online version:10.1126/science.1061052
Keywords	Animals; Bacterial Proteins/chemistry; Bacterial Proteins/genetics; Carbon/analysis; Ecology; Escherichia coli/chemistry; Escherichia coli/enzymology; Escherichia coli/genetics; Evolution, Molecular; Fungal Proteins/chemistry; Fungal Proteins/genetics; Humans; Nitrogen/analysis; Rats; Saccharomyces cerevisiae/chemistry; Saccharomyces cerevisiae/enzymology; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/metabolism; Sulfur/analysis
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